Polycystic ovarian disease: heritability and heterogeneity
نویسندگان
چکیده
منابع مشابه
Polycystic ovarian disease: heritability and heterogeneity.
The polycystic appearance of the ovary is the distinguishing characteristic of polycystic ovary syndrome (PCOS) but there is a wide range of other clinical and biochemical features, e.g. elevated serum concentrations of androgens, insulin, LH and decreased insulin sensitivity. The high prevalence of affected individuals and the wide range of related phenotypes can be explained by the interactio...
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1. The authors state that lipid abnormality may occur in polycystic ovary syndrome (PCOS) irrespective of insulin resistance (IR) in overweight and obese women. Indian literature showed that about one fourth of PCOS women have normal body mass index (BMI) [2]. PCOS women with normal BMI are very difficult to treat and monitor. Does the lipid abnormality exit in this category of women also, and ...
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Polycystic ovarian disease (PCOD) is most common endocrine disorder in women. Symptoms are variable and often involve more than one body function. The major clinical features are hirsutism, menstrual irregularities, obesity, insulin resistance, hyperinsulinemia, polycystic ovaries (PCO). Other characteristics include malepattern balding, acanthosis negricans, sleep apnea with increased risk for...
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Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder with genetic heterogeneity. Up to three loci are involved in this disease, PKD1 on chromosome 16p13.3, PKD2 on 4q21, and a third locus of unknown location. Here we report the existence of locus heterogeneity for this disease in the Argentinian population by performing linkage analysis on 12 families of Caucasian origi...
متن کاملPolycystic ovarian syndrome.
Polycystic ovarian syndrome (PCOS) is the most common reproductive endocrinopathy of women during their childbearing years. A significant degree of controversy exists regarding the etiology of this syndrome, but there is a growing consensus that the key features include insulin resistance, androgen excess, and abnormal gonadotropin dynamics. Familial and genetic factors cause predisposition to ...
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ژورنال
عنوان ژورنال: Human Reproduction Update
سال: 2001
ISSN: 1355-4786,1460-2369
DOI: 10.1093/humupd/7.1.3